Fort Myers is the county seat and commercial center of Lee County, Florida. Its population was 48,208 in the 2000 census. According to the 2006 U.S. Census Bureau's estimates, the population was 60,531.

The city is one of two major cities that make up the Cape Coral-Fort Myers MSA, the other being Cape Coral. As of July 1, 2006, the population estimate for the metropolitan area was 571,344.

Established in 1886, Fort Myers is the historical and governmental hub of Lee County. It is the gateway to the Southwest Florida region, which is a major tourist destination in Florida. The winter homes of Thomas Edison (Seminole Lodge) and Henry Ford (The Mangoes), which are both primary tourist attractions in the region, are located on McGregor Boulevard in Fort Myers.

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